The International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network is a global collaboration of investigators, institutions, community representatives and other partners organized for the purpose of evaluating interventions to treat and prevent HIV infection and its consequences in infants, children, adolescents and pregnant/postpartum women through the conduct of high quality clinical trials.
The IMPAACT Network's research agenda includes evaluation of: new and existing anti-HIV drugs and formulations; novel approaches for addressing tuberculosis in HIV-infected or at-risk populations; biomedical/behavioral interventions to prevent mother-to-child HIV transmission; immunogenicity, safety and efficacy of high priority vaccines; potential for HIV cure through therapeutic interventions; and methods to prevent and manage complications and comorbidities of HIV infection and its treatment.
IMPAACT was formed in 2006 through a merger of investigators from the Pediatric AIDS Clinical Trials Group (PACTG) and the Perinatal Scientific Working Group of the HIV Prevention Trials Network (HPTN). The Network is directed by a leadership group led by Chair, Sharon Nachman, MD, of the University of New York at Stony Brook, and Vice-Chair James McIntyre, MD, of the Anova Health Institute and the University of Cape Town.
FHI 360 serves as the Coordinating and Operations Center for the Network. The Harvard School of Public Health and Frontier Science and Technology Research Foundation (FSTRF) form the Statistical and Data Management Center (SDMC), and the Network's Central Laboratory is located at the University of Southern California.
IMPAACT is primarily funded by the Division of AIDS (DAIDS), National Institute of Allergy and Infectious Diseases (NIAID), US National Institutes of Health (NIH), and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, and the National Institute of Mental Health (NIMH), NIH.
To learn more about the IMPAACT Network, processes, and structure, click here for a PDF presentation.