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Research Areas

HIV Cure

The IMPAACT HIV Cure Scientific Committee aims to evaluate the potential for HIV cure through therapeutic interventions directed at prevention and clearance of HIV reservoirs in HIV-infected infants, children and adolescents. Due to the known timing of acute infection in newborns and potentially stronger immune systems in youth, interventions to achieve a cure or functional cure are promising in these populations. Priorities include evaluation of:

  • Whether very early therapy with intensified combination antiretroviral therapy (ART), that includes agents that block virus entry and/or integration, prevents HIV reservoir establishment in infants.
  • Unique cohorts of HIV-infected children and youth likely to achieve cure through interventions that stimulate latent proviruses and enhance HIV-specific immunity.
  • Immune modulatory agents, including therapeutic HIV vaccines, virus activation or target cell modification strategies to affect cure in perinatally and behaviorally infected youth on long-term suppressive combination ART.
  • Active and passive HIV-specific immunizations for intrapartum and postpartum PMTCT as well as HIV-specific vaccines as therapeutic immunization.

Committee Contacts

Chair: Deborah Persaud
Vice-Chair: Ellen Chadwick
Operations Center: Anne Coletti and Charlotte Perlowski

Presentations

2016 IMPAACT Annual Meeting Cure Scientific Committee presentations

2015 IMPAACT Annual Meeting Cure Scientific Committee presentation

Studies Within This Research Area

IMPAACT 2015
IMPAACT 2008
IMPAACT P1115
IMPAACT P1107

 

 

 

 

 

 

 

 

 

 

 

Funded by the National Institute of Allergy and Infectious Diseases, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the National Institute of Mental Health of the US National Institutes of Health, US Department of Health and Human Services.