Request for Applications (RFA):
Pedigreed Biological Specimens for IMPAACT Network Supported Investigations Accessible through a New Specimen Biorepository Utility


The US National Institutes of Health (NIH)-sponsored International Maternal Pediatric Adolescent Clinical Trials (IMPAACT) Network aims to increase investigator access to and use of stored biological specimens available at both the National Institute of Allergy and Infectious Diseases (NIAID) Biomedical Research Institute (BRI) repository and the Fisher Scientific repository, both in Rockville, Maryland, for new laboratory-based scientific investigations. Specimen types stored at these repositories include cerebrospinal fluid (CSF), cord blood, viable peripheral blood mononuclear cells (PBMCs), non-viable PBMCs, plasma, viable polymorphonuclear leukocytes, serum, whole blood, and whole blood pellets.  Investigators can use the interactive search tool at to learn about the types and numbers of specimens available, information about the studies for which they were collected (listed below), and publications associated with those studies.

Specimens are also available from studies performed under the AIDS Clinical Trials Group (ACTG). These include blood, serum, plasma, sputum, peripheral blood mononuclear cells (PBMC), tissue, and other body fluids such as CSF, endocervical and cervicovaginal lavage fluid from studies involving populations over 18 years of age. The ACTG has also issued a similar RFA; more information is available at


The purpose of this RFA is to encourage collaboration with investigators and the IMPAACT Network by providing access to and funding support for use of pedigreed biological specimens in novel laboratory-based investigations. This funding opportunity is open to all qualified investigators, whether or not they are affiliated with the IMPAACT Network.


IMPAACT New Works Concept Sheet (NWCS)
Budget Justification
Budget Template


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Funded by the National Institute of Allergy and Infectious Diseases, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the National Institute of Mental Health of the US National Institutes of Health, US Department of Health and Human Services.