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IMPAACT P1104s Results Released


The IMPAACT Network is excited to announce the publication of primary results from the IMPAACT P1104s study in Clinical Infectious Diseases. A NIAID news release related to the publication is available here.

IMPAACT P1104s was an observational, longitudinal cohort study of HIV-infected children and HIV-uninfected controls (both perinatally-exposed to HIV and non-exposed), designed to assess the feasibility, reliability, and validity of administering a neuropsychological assessment battery and to compare neuropsychological outcomes between the study groups cross-sectionally and longitudinally over 3 years. The study was conducted at six IMPAACT clinical research sites in Malawi, South Africa, Uganda, and Zimbabwe. Baseline results from the study were previously published in AIDS in January 2018.

Baseline results demonstrated neurocognitive differences between children with HIV when compared to children exposed to HIV in utero but uninfected and children never exposed to HIV. The neurocognitive evaluations included cognitive ability, motor function, and attention. These recently published results build on the baseline results and demonstrate sustained neurocognitive differences over two years of study follow-up.

 

Reference: Boivin MJ, Chernoff M, Fairlie L, Laughton B, Zimmer B, Joyce C, Barlow-Mosha L, Bwakura-Dangarembizi M, Vhembo T, Ratswana M, Kamthunzi P, McCarthy K, Familiar-Lopez I, Jean-Philippe P, Coetzee J, Abrahams N, Gous H, Violari A, Palumbo P. African Multi-Site 2-Year Neuropsychological Study of School-Age Children Perinatally Infected, Exposed, and Unexposed to Human Immunodeficiency Virus. Clinical Infectious Diseases DOI: 10.1093/cid/ciz1088 (2019).


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Funded by the National Institute of Allergy and Infectious Diseases, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the National Institute of Mental Health of the US National Institutes of Health, US Department of Health and Human Services.