A5241 (10395): The Optimized Treatment That Includes or Omits NRTIs (OPTIONS) Trial: A Randomized Strategy Study for HIV-1-Infected Treatment-Experienced Subjects Using the cPSS to Select an Effective Regimen
| Study Status | Study Restriction |
|---|---|
Participants Off Study and Primary Analysis Completed |
United States |
What is A5241?
A5241 is an open-label, Phase III prospective randomized strategy study for HIV-1-infected subjects who have treatment experience with or resistance to nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors (PIs). This study will evaluate the benefit of adding NRTIs to a novel antiretroviral regimen. The major secondary goal of the study is to evaluate the relative potency of the regimen as assessed by the continuous phenotype susceptibility score (cPSS) and treatment regimen response.
Sites where the study is implemented:
| CRS ID | Site Name | City | Country |
|---|---|---|---|
Texas Childrens Hosp. CRS |
Houston |
United States of America |
|
Chicago Children's CRS |
Chicago |
United States of America |
|
University of Miami Pediatric/Perinatal HIV/AIDS |
Miami |
United States of America |
|
Boston Medical Center Pediatric HIV Program |
Boston |
United States of America |
|
San Juan City Hospital |
San Juan |
United States of America |
|
University of Southern California LA |
Los Angeles |
United States of America |
|
University of Florida Jacksonville |
Jacksonville |
United States of America |
|
South Florida CDTC Ft Lauderdale NICHD CRS |
Fort Lauderdale |
United States of America |
|
Rush University Cook County Hospital Chicago NICHD CRS |
Chicago |
United States of America |
|
Johns Hopkins University, Baltimore |
Baltimore |
United States of America |
|
UCLA - David Geffen School of Medicine |
Los Angeles |
United States of America |
|
Bronx-Lebanon Hospital IMPAACT |
Bronx |
United States of America |
|
St. Jude/UTHSC CRS |
Memphis |
United States of America |
|
University of Puerto Rico Pediatric HIV/AIDS Research Program CRS |
San Juan |
United States of America |
Study contacts:
Chair: Karen Tashima
Co-Chair: Richard Haubrich
CTS: Katie McCarthy