ATN 052 (10368): Population Genetics and Immune Response to Hepatitis B Vaccination in Adolescents: A Substudy of ATN 024 and ATN 025

Study Status Study Restriction


Not Applicable

What is ATN 052?

ATN 052 was a laboratory-based study that was designed to study how individuals differ in their immune responses to the hepatitis B vaccines.  These vaccines make specific proteins called antibodies that protect people against hepatitis B virus (HBV) infection if they come into contact with the virus.  The benefits of safe and effective vaccination can be less than expected because some individuals do not produce enough of these antibodies.  Different forms of human genes and other factors like age and gender may account for occasional failure in vaccination.  The goal of ATN 052 was to test if genetic differences are indeed related to antibody response to hepatitis B vaccine.

Sites where the study was implemented:

CRS ID Site Name City Country

Study contacts:

Study Chair: Jianming Tang

Study Vice-Chair: Craig Wilson

CTS: Katie McCarthy


Funded by the National Institute of Allergy and Infectious Diseases, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the National Institute of Mental Health of the US National Institutes of Health, US Department of Health and Human Services.