IMPAACT 2002

IMPAACT 2002 is multi-site, two-arm, cluster-randomized study to examine if a Health and Wellness Cognitive Behavioral Therapy and Medication Management for depression improves outcomes for HIV-infected youth in the United States. Approximately 130 HIV-infected youth, ages 14-24 with depression, will be assigned to either Health and Wellness Cognitive Behavioral Therapy and Medication Management group or the Enhanced Standard of Care group and followed for 48 weeks. The study will examine whether participants receiving Health and Wellness Cognitive Behavioral Therapy and Medication Management Algorithm treatment for depression demonstrate improved depression outcomes and improved biological measures of health compared to participants receiving the Enhanced Standard of Care therapy.