P1080 / ARV & Psychiatric Medication Concentrations in HIV Infected & Uninfected Children

P1080 is a pilot PK study that will describe the pharmacokinetics of the selected psychiatric medications currently prescribed in HIV-1 infected and uninfected children and adolescents.  Under version 1.0, the specific psychiatric medications were methylphenidate or amphetamine/dextroamphetamine alone (in HIV-uninfected children) or in combination with an EFV-based or a ritonavir-based ARV regimen (in HIV-infected children).  The target enrollment is 90 evaluable subjects > 6 to < 25 years of age; duration of participation is up to 14 months.