Manuscripts

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Showing 1543 manuscripts.

Population Pharmacokinetic Modeling of Dolutegravir to Optimize Pediatric Dosing in HIV-1-Infected Infants, Children, and Adolescents

Theodore Ruel, David Burger, Andrew Wiznia, Edward P. Acosta, Lee Fairlie, Rajendra Singh, Lucy Koech, IMPAACT P1093 and ODYSSEY (PENTA 20) Study Teams, Mutsawashe Bwakura-Dangarembizi, Hilda Mujuru, Adeodata R. Kekitiinwa, Cissy M. Kityo, Carmelita Alvero, Hardik Chandasana, Mona Farhad, Mita Thapar, Rohan Hazra, Siobhan Hayes, Ellen Townley, Mark Baker, Ann Buchanan, Diana M Gibb, Pauline Bollen, Anna Turkova, Hylke Waalewijn, Deborah Ford, Angela Colbers. Population Pharmacokinetic Modeling of Dolutegravir to Optimize Pediatric Dosing in HIV-1-Infected Infants, Children, and Adolescents. Clinical Pharmacokinetics. 62: 1445-1459. PMID: 37603217

Journal

Clinical Pharmacokinetics

Study

P1093

Impact of Genetic Variants in ABCG2, NR1I2 and UGT1A1 on the Pharmacokinetics of Dolutegravir in Children

Audrey Chang, Andrew Wiznia, Theodore D. Ruel, Edward P. Acosta, IMPAACT 1093 Team, Stephen A. Spector, Sean S. Brummel. Impact of Genetic Variants in ABCG2, NR1I2 and UGT1A1 on the Pharmacokinetics of Dolutegravir in Children. Journal of Acquired Immune Deficiency Syndromes. 95: doi: 10.1097/QAI.000000000000335. PMID: 38180896

Journal

Journal of Acquired Immune Deficiency Syndromes

Study

P1093

Bridging Dolutegravir Clinical Viral Response Across Doses and Formulations Using Model-Based Exposure-Response Analysis in Pediatrics

Ellen Townley, Rohan Hazra, Kathy George, Cindy Vavro, Theodore Ruel, Edward Acosta, IMPAACT P1093 Team, Hardik Chandasana, Rajendra Singh, Annie Buchanan, Cynthia Brothers, Andy Wiznia, Mattie Bartlett, Stephanie Popson. Bridging Dolutegravir Clinical Viral Response Across Doses and Formulations Using Model-Based Exposure-Response Analysis in Pediatrics. PMID: 38768443

Study

P1093

Prevalence of detectable HIV-DNA and HIV-RNA in cerebrospinal fluid of youth with perinatal HIV and impaired cognition on antiretroviral therapy

Murli Purswani, Allison Bearden, Andrew Wiznia, Allison Agwu, Thor A. Wagner, Ellen G. Chadwick, Camlin Tierney, Douglas Richman, Sharon Huang, Monica Gandhi, Sharon Nichols, Patrick Mehta, Kathleen M. Malee, Bernard Macatangay, Nicole A. Montañez, Stephen A. Spector, Anne Coletti, Serena Spudich, Hans ML Spiegel, Deborah Persaud, Chelsea Krotje, Ann Chahroudi, Frederic Bone, IMPAACT 2015 Protocol Team, Megan Wilkins, Lisa Abuogi. Prevalence of detectable HIV-DNA and HIV-RNA in cerebrospinal fluid of youth with perinatal HIV and impaired cognition on antiretroviral therapy. AIDS. 38: 1494-1504. PMID: 38814693

Journal

AIDS

Study

IMPAACT 2015

Pharmacokinetics and Safety of Remdesivir in Pregnant and Non-Pregnant Women with COVID

Christy Beneri, Kathryn Kersey, Jaime G. Deville, Rita Humeniuk, Kathleen Powis, Brookie M. Best, Alice M. Stek, Mark Mirochnick, Ahizechukwu Eke, Jeremiah D. Momper, David E. Shapiro, IMPAACT 2032 Study Team, Edmund Capparelli, Elizabeth Greene, Kathleen George, Kristina M. Brooks, Dwight E. Yin, Kristin Baltrusaitis, Patrick Jean-Philippe, Diana F. Clarke, Nahida Chakhtoura, Sharon Nachman, Frederic Bone, Jennifer Jao, Kira Bacon, Murli Purswani, Benjamin Johnston, Allison Agwu, Christina Reding. Pharmacokinetics and Safety of Remdesivir in Pregnant and Non-Pregnant Women with COVID. Journal of Infectious Diseases. PMID: 38839047

Journal

Journal of Infectious Diseases

Study

IMPAACT 2032

Population Pharmacokinetic Modeling of Abacavir/Dolutegravir/Lamivudine to Support a Fixed-Dose Combination in Children with HIV-1

Rashmi Mehta, Mark Bush, Helena Rabie, Patricia Flynn, Tim R. Cressey, Edward P. Acosta, Kristina M. Brooks, IMPAACT 2019 Study Team, Hardik Chandasana, Sven C. van Dijkman. Population Pharmacokinetic Modeling of Abacavir/Dolutegravir/Lamivudine to Support a Fixed-Dose Combination in Children with HIV-1. Infectious Diseases and Therapy. PMID: 38961048

Journal

Infectious Diseases and Therapy

Study

IMPAACT 2019

Dolutegravir- Versus Efavirenz-Based Treatment in Pregnancy: Impact on Red Blood Cell Folate Concentrations in Pregnant Women and Their Infants

Patricia DeMarrais, Lena Serghides, Sean Brummel, Nahida Chakhtoura, Mindy Zhang, Lameck Chinula, Christine M. Pfeiffer, Shahin Lockman, Cynthia A. Moore, Katie McCarthy, Benjamin Johnston, Terence Mohammed, Tichaona Vhembo, Enid Kabugho, Gerald Agaba Muzorah, Haseena Cassim, Lee Fairlie, Elizabeth S. Machado, Denise L. Jacobson, James S. Ngocho, Krista S. Crider, Roger L. Shapiro. Dolutegravir- Versus Efavirenz-Based Treatment in Pregnancy: Impact on Red Blood Cell Folate Concentrations in Pregnant Women and Their Infants. PMID: 38877762

Study

IMPAACT 2010

Markers of maternal bone and renal toxicity through 50 weeks postpartum: IMPAACT 2010 (VESTED) Trial

Lauren Ziemba, Judith Currier, John Shepherd, Risa Hoffman, Tapiwa Mbengeranwa, Lameck Chinula, Laarni Igawa, Paul E. Sax, Anne Coletti, Lynda Stranix-Chibanda, Dorinda Mukura, IMPAACT 2010/VESTED study team and investigators, Lindie Rossouw, Gerhard Theron, Chelsea Krotje, Patrick Jean-Philippe, Nahida Chakhtoura, Haseena Cassim, Sisinyana Ruth Mathiba, Joel Maena, Gaerolwe Masheto, William Murtaugh, Sean S Brummel, Lee Fairlie. Markers of maternal bone and renal toxicity through 50 weeks postpartum: IMPAACT 2010 (VESTED) Trial. Journal of Acquired Immune Deficiency Syndromes.

Journal

Journal of Acquired Immune Deficiency Syndromes

Study

IMPAACT 2010

Effects of preterm birth, maternal ART and breastfeeding on 24-month infant HIV-free survival in a randomized trial

Mauricio Pinilla, Katie S. McCarthy, Lameck Chinula, Renee Browning, Maxensia Owor, Lynne M. Mofenson, Avy Violari, Sean S. Brummel, Dhayendre Moodley, Mary Glenn Fowler, Lynda Stranix-Chibanda, PROMISE 1077BF/FF Team, Taguma Allen Matubu, Gift Tafadzwa Chareka, Gerhard Theron, Aarti Avinash Kinikar, Mwangelwa Mubiana-Mbewe, Lee Fairlie, Raziya Bobat, Blandina Theophil Mmbaga, Sufia Dadabhai, Patricia M. Flynn, Victoria B. Chou, Taha E. Taha. Effects of preterm birth, maternal ART and breastfeeding on 24-month infant HIV-free survival in a randomized trial. AIDS. PMID: 38427596

Journal

AIDS

Impact of HIV drug resistance mutations detected in women prior to antiretroviral therapy with efavirenz + tenofovir + lamivudine (or emtricitabine)

PROMISE Study Team, Ceejay L. Boyce, Tatiana Sils, Ross S. Milne, Jackson J. Wallner, Samantha R. Hardy, Daisy Ko, Annie Wong-On-Wing, Malia Mackey, Nikki Higa, Ingrid A. Beck, Sheila M. Styrchak, Patricia DeMarrais, Camlin Tierney, Mary G. Fowler, Lisa M. Frenkel. Impact of HIV drug resistance mutations detected in women prior to antiretroviral therapy with efavirenz + tenofovir + lamivudine (or emtricitabine). Lancet HIV.

Journal

Lancet HIV